The glucagon-like peptide-1 receptor (GLP-1R) is a seven transmembrane (7TM) G protein-coupled receptor (GPCR) and its natural
نویسندگان
چکیده
PEPTIDE-1 RECEPTOR EXTRACELLULAR DOMAIN Steffen Runge, Henning Thøgersen, Kjeld Madsen, Jesper Lau and Rainer Rudolph. From Department of Structure and Biophysical Chemistry and Department of Protein and Peptide Chemistry, Novo Nordisk, 2760 Måløv, Denmark. Institute of Biotechnology, Martin-Luther University, Halle-Wittenberg, 06120 Halle (Saale), Germany. Address correspondence to: Steffen Runge, Novo Nordisk Park G8.S.439, DK-2760 Måløv, Denmark. Phone: +4544434431, Phone: +4530754431, Fax: +45 [email protected]
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Structural insight into antibody-mediated antagonism of the Glucagon-like peptide-1 Receptor
The Glucagon-like peptide-1 receptor (GLP-1R) is a member of the class B G protein-coupled receptor (GPCR) family and a well-established target for the treatment of type 2 diabetes. The N-terminal extracellular domain (ECD) of GLP-1R is important for GLP-1 binding and the crystal structure of the GLP-1/ECD complex was reported previously. The first structure of a class B GPCR transmembrane (TM)...
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